Abstract: Chronic Kidney Disease (CKD) often presents with distressing cutaneous manifestations, including uremic xerosis, hyperpigmentation, and pruritus. This review examines the therapeutic potential of topical application of Avena Sativa in alleviating these dermatological symptoms in CKD patients. Avena Sativa, commonly known as oat extract, has shown promise in various skincare applications due to its anti-inflammatory, antioxidant, and moisturizing properties. This article comprehensively explores existing literature, clinical studies, and experimental evidence to provide insights into the efficacy, safety, and mechanisms of action of Avena Sativa in managing cutaneous complications associated with CKD.